Erection of the penis is associated with stagnation of blood in the penis. This is due to the increased blood flow and reduces the outflow from the penis. Under normal conditions of sexual stimulation causes the production and release of nitric oxide to the penis. It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. This may because a pronounced reduction in tone of smooth muscle cells in the case of blood vessels appears dangerous fall in blood pressure. This fact is the reason why the use of nitrates is a strict contraindication for the use of inhibitors of type 5 inhibitors.

Three drugs of this group existing on the market today - Sildenafil, Tadalafil and Vardenafil are competitive and reversible inhibitors of hydrolysis of the cyclic catalytic center of the molecule inhibitors of type 5. Erectile dysfunction (ED), also known as impotence, is the inability to achieve or sustain an erection for satisfactory sexual activity. Before we proceed to the consideration of clinical issues, we briefly discuss the main pharmacodynamics and pharmacokinetic properties of these drugs.


Not recommended taking the drug with other drugs to increase potency because the clinical implications of such a method are not known. Compared with healthy subjects from patients with renal insufficiency moderately received complaints of back pain when using the drug Cialis Soft - http://onstorerx.com/cialis-soft-usa.html. Anti-hypertensives may be used alone or in combination to control blood pressure. Side effects of Tadalafil in patients with severe renal impairment (creative clearance of 30 ml/min) have not been studied. Patients with creative clearance of 50 ml/min with a drug are given a high degree of caution.



It's no secret that alcohol increases sexual desire. It has been found to be effective in treating erectile dysfunction in men with coronary artery disease, diabetes mellitus, hypertension, depression, coronary artery bypass surgery, and men who are taking antidepressants and several classes of anti-hypertensives.

According to clinical studies the concentration of the active substance Vardenafil is not reduced by the use of alcohol. However, the possible decrease in blood pressure. The instructions given to the drug that you cannot drink more than:


  • 5 Glasses of wine

  • 5 Servings of vodka or whiskey

  • 2 liters of beer


If drinking large amounts of alcohol cannot be avoided then you need to consult a doctor for the correct dosage of the drug, so as not to harm the body and keep the action exciting tablets.